Cyanostilbenes as Selective Chloride Carriers Relying on CH‐anion Interactions

Q: What type of study is this?

This is a In Vitro Study study.

Anurag Singh; Lau Halgreen; Priyanka Rani Panda; Aarón Torres‐Huerta; Nikolay Tumanov; Johan Wouters; Hennie Valkenier

doi:10.1002/chem.202502050

August 19, 2025Chemistry - A European Journal

Cyanostilbenes as Selective Chloride Carriers Relying on CH‐anion Interactions

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Key Points

The compound with four trifluoromethyl groups showed the highest affinity for chloride, transporting it rapidly across membranes.
The study identified selective transport capabilities for chloride over other anions, including bicarbonate and fluoride.
By employing CH-based hydrogen bonds, this approach diverges from traditional NH-based methods in anion receptor design.
Overall, findings suggest a promising future for these cyanostilbene-based receptors in treating chloride channel disorders.},
simple_explanation":"Cyanostilbenes are special compounds that can help transport chloride ions across cell membranes. A new type of these compounds, designed with specific chemical groups, works faster and better than previous designs. This selectivity for chloride could be important for treating conditions that affect chloride channels in the body. They might improve treatments for diseases linked to these channels. 🌊"} ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 🧪"} 🧪 🧪 🧪 🧪 🧪 🧪 🧪 🧪 🧪 🧪 🧪 🧪 🧪 🧪
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Implication

Research demonstrates enhanced chloride transport and selectivity in small receptors, indicating potential for chloride channelopathies treatment.

Abstract

Achieving selectivity is one of the challenges in developing anion receptors for transmembrane transport. This can be achieved through larger molecular designs that encapsulate the anion efficiently or by using alternative binding motifs instead of the most commonly used NH-based hydrogen bond donors. In this study, we present a series of small chloride receptors based on α-cyanostilbenes that use CH-based hydrogen bonds. By varying the substituents, we discovered that the compound containing four trifluoromethyl groups and a nitro group in addition to the two cyano groups exhibited the greatest affinity for chloride and the fastest chloride transport rates, surpassing the performance of reported triazole-based compound. Furthermore, this compound showed clear selectivity for transporting chloride over hydroxide, bicarbonate, and fluoride anions. The activity, selectivity, and deliverability of this compound make it a promising candidate for the treatment of chloride channelopathies.

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Cite This Study

Singh et al. (2025) studied this question.

synapsesocial.com/papers/68af4551ad7bf08b1ead38e2 https://doi.org/10.1002/chem.202502050

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Cyanostilbenes as Selective Chloride Carriers Relying on CH‐anion Interactions

Key Points

Implication

Abstract

Discussion

Cite This Study

Cyanostilbenes as Selective Chloride Carriers Relying on CH‐anion Interactions

Key Points

Implication

Abstract

Discussion

Cite This Study

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