August 5, 2025Nucleic Acids ResearchOpen Access

Genome-wide in vivo and ex vivo mapping of R-loops using engineered N-terminal hybrid-binding domain of RNase H3 (enDR3)

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Observational analysis confirms enDR3 improves r-loop detection in genome-wide studies, suggesting enhanced accuracy in mapping techniques.

enDR3 enables robust detection of r-loops, showcasing its significance in genomic studies.
Key evidence shows enDR3's ability to capture and sequence rna/dna hybrids for enhanced precision.
Observed in both in vitro and in vivo conditions, enDR3 offers a reliable alternative to traditional methods.
This tool may advance understanding of genome instability linked to human diseases, calling for further exploration.

Jedynak-Slyvka et al. (2025) studied this question.

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August 5, 2025Nucleic Acids ResearchOpen Access

View Full Paper

Ask AI

Bookmark

Authors

Observational analysis confirms enDR3 improves r-loop detection in genome-wide studies, suggesting enhanced accuracy in mapping techniques.

enDR3 enables robust detection of r-loops, showcasing its significance in genomic studies.
Key evidence shows enDR3's ability to capture and sequence rna/dna hybrids for enhanced precision.
Observed in both in vitro and in vivo conditions, enDR3 offers a reliable alternative to traditional methods.
This tool may advance understanding of genome instability linked to human diseases, calling for further exploration.

Jedynak-Slyvka et al. (2025) studied this question.

View Full Paper

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Bookmark