August 14, 2025CureusOpen Access

Immune Checkpoint Inhibitor-Induced Myositis Myocarditis and Myasthenia Gravis (MMM) Overlap Syndrome in a Rural District General Hospital: An Institutional Case Series Involving Four Patients

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Authors

UIUmar IsmailHywel Dda University Health Board EBElisabeta E BothHywel Dda University Health Board HBHelen BrownCardiff University

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Implication

Case series reports outcomes of 4 male patients with ICI-induced myositis, myocarditis, and myasthenia gravis, highlighting challenges in rural healthcare settings.

Key Points

Four patients presented with ICI-induced myositis and myocarditis, with varying outcomes, indicating the need for prompt treatment.
Among the cohort, 50% survived after treatment, while others succumbed to respiratory failure linked to delayed care.
Assessment included various biomarkers; however, access to diagnostics for myasthenia gravis was limited in this rural setting.
Findings underscore the necessity for tailored management guidelines to facilitate timely interventions in low-resource environments.

Cite This Study

Ismail et al. (2025) studied this question.

synapsesocial.com/papers/68af474ead7bf08b1ead3ce5 https://doi.org/10.7759/cureus.90106

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Implication

Case series reports outcomes of 4 male patients with ICI-induced myositis, myocarditis, and myasthenia gravis, highlighting challenges in rural healthcare settings.

Immune Checkpoint Inhibitor-Induced Myositis Myocarditis and Myasthenia Gravis (MMM) Overlap Syndrome in a Rural District General Hospital: An Institutional Case Series Involving Four Patients

Discussion

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Implication

Key Points

Cite This Study

Immune Checkpoint Inhibitor-Induced Myositis Myocarditis and Myasthenia Gravis (MMM) Overlap Syndrome in a Rural District General Hospital: An Institutional Case Series Involving Four Patients

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Implication

Key Points

Cite This Study

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