Novel di-aryl chalcone derived pyrazole linked to methane sulfonyl pharmacophore as potent selective COX-2 inhibitors; design, synthesis, molecular modeling, in vitro and in vivo anti-inflammatory activities

Q: What type of study is this?

This is a In Vitro Study study (also classified as: Animal Study).

Abeer M. Abd El-Hameed; Ahmed H. Lotfallah; Mohamed T. M. Nemr; Hoda Khalifa Abdelhady; Haredy Hassan Haredy; Ahmed M. Sayed; Mamdouh F. A. Mohamed; Deiaa E Elsayed Abouzed; Wael A.A. Fadaly

doi:10.1080/17568919.2025.2545171

August 17, 2025Future Medicinal Chemistry

Novel di-aryl chalcone derived pyrazole linked to methane sulfonyl pharmacophore as potent selective COX-2 inhibitors; design, synthesis, molecular modeling, in vitro and in vivo anti-inflammatory activities

View Full Paper

Ask AI

Bookmark

Share

Key Points

The di-aryl chalcone derived pyrazole shows significant COX-2 inhibition, which may enhance anti-inflammatory treatments.
In vitro and in vivo tests revealed that the novel compound markedly outperformed existing COX-2 inhibitors.
Synthesis involved designing and evaluating pyrazole linked to methane sulfonyl, aiming for improved selectivity.
These findings support further development of selective inhibitors for effective anti-inflammatory therapies.

Implication

Novel di-aryl chalcone derived pyrazole exhibits potent COX-2 inhibition in vitro and in vivo, suggesting potential therapeutic applications.

Abstract

Aim Based on the structural features of both lonazolac and celecoxib, as an attempt to improve COX-2 selectivity, a series of novel di-aryl-chalcone derived pyrazole (16a-l) was designed, synthesized, and evaluated for its COX-2 selective anti-inflammatory inhibitory activity.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

El-Hameed et al. (2025) studied this question.

synapsesocial.com/papers/68af4754ad7bf08b1ead3d19 https://doi.org/10.1080/17568919.2025.2545171

View Full Paper

Ask AI

Bookmark

Share

Novel di-aryl chalcone derived pyrazole linked to methane sulfonyl pharmacophore as potent selective COX-2 inhibitors; design, synthesis, molecular modeling, in vitro and in vivo anti-inflammatory activities

Key Points

Implication

Abstract

Discussion

Cite This Study

Novel di-aryl chalcone derived pyrazole linked to methane sulfonyl pharmacophore as potent selective COX-2 inhibitors; design, synthesis, molecular modeling, in vitro and in vivo anti-inflammatory activities

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading