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This is a In Vitro Study study.

August 17, 2025Scientific ReportsOpen Access

Utility of 3-(2-oxo-2H-chromen-3-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde in the synthesis of novel 1,3,4-thiadiazoles or 1,3-thiazoles and study their cytotoxic activity

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Cytotoxic activity of new coumarin compounds shows growth inhibition in human cancer cells, highlighting their potential as anticancer agents.

Compounds 3a, 3b, 6, 8a, b, and 10b showed up to 96% growth inhibition against various cancer cell lines.
Compound 6 demonstrated notable lethality against melanoma MDA-MB-435 and renal cancer A498 with growth percentages of -47.47 and -6.20 respectively.
In vitro testing revealed significant cytotoxic activity of synthesized coumarins linked to thiadiazoles and thiazoles against 60 human cancer cell lines.
The promising anticancer efficacy supports further research on these novel compounds for potential cancer therapies.

Abdel‐Aziem et al. (2025) studied this question.

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Cytotoxic activity of new coumarin compounds shows growth inhibition in human cancer cells, highlighting their potential as anticancer agents.