A New Generation of N-Heterocyclic Carbene (NHC) Gold-Selenolato Complexes as Potent Anticancer Agents: Distinct Synthetic Routes and Evaluation in 2D and 3D Cancer Models

Pierre Arnaut; Nestor Bracho Pozsoni; Denys Bondar; Petra Lippmann; Susanne Boschuk; Ivan Semenyuta; Subhrajyoti Bhandary; Kristof Van Hecke; Yevgen Karpichev; Georgios C. Vougioukalakis; Ingo Ott; Nikolaos V. Tzouras; Steven P. Nolan; Thomas Scattolin; Flavio Rizzolio; Enrico Cavarzerani; Vincenzo Canzonieri

doi:10.1039/d5sc04490a

January 1, 2025Chemical ScienceOpen Access

A New Generation of N-Heterocyclic Carbene (NHC) Gold-Selenolato Complexes as Potent Anticancer Agents: Distinct Synthetic Routes and Evaluation in 2D and 3D Cancer Models

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Key Points

These new gold-selenolato complexes exhibit potent anticancer activity, enhancing treatment options in oncology.
The research provides insight into two distinct synthetic pathways facilitating complex formation effectively.
Characterization of these complexes was done using evaluations in both 2D and 3D cancer models for comprehensive analysis.
These findings suggest NHC-stabilized complexes could impact future cancer therapies, warranting further exploration.

Implication

Synthetic routes yield new gold-selenolato complexes, demonstrating potential as anticancer agents in cancer models.

Abstract

Two distinct synthetic pathways are disclosed that lead to new coinage metal-selenolato complexes, stabilized by N-heterocyclic carbenes (NHCs). The weak base route can provide facile access to phenylselenolate complexes of...

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Arnaut et al. (2025) studied this question.

synapsesocial.com/papers/68af4754ad7bf08b1ead3eac https://doi.org/10.1039/d5sc04490a

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A New Generation of N-Heterocyclic Carbene (NHC) Gold-Selenolato Complexes as Potent Anticancer Agents: Distinct Synthetic Routes and Evaluation in 2D and 3D Cancer Models

Key Points

Implication

Abstract

Discussion

Cite This Study

A New Generation of N-Heterocyclic Carbene (NHC) Gold-Selenolato Complexes as Potent Anticancer Agents: Distinct Synthetic Routes and Evaluation in 2D and 3D Cancer Models

Key Points

Implication

Abstract

Discussion

Cite This Study

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