Case report reveals abnormal VEP latency in patient with multiple sclerosis, suggesting myelination effects.
Aberrant myelination of the retinal nerve fibre layer (RNFL) can follow lamina cribrosa damage. Such cases may provide insight into how increased myelin affects the visual evoked potential (VEP), a key outcome in remyelination trials. We present the case of a myelinated RNFL in a patient with relapsing-remitting multiple sclerosis (RRMS) with accompanying electrophysiology. Visual assessments used a VisionSearch Plus, Heidelberg Spectralis optical coherence tomography, and Topcon fundus camera. Full-field visual evoked potential (FF-VEP) peak time latency was abnormally short, 90 ms. This is the first known case report of a myelinated RNFL with electrophysiology, which supports the assertion that reductions in VEP latency correlate with myelination.
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Riboni-Verri et al. (2025) studied this question.
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