Tandem cyclization produces all-carbon tetrasubstituted compounds in ortho-alkynylnaphthols and p-quinone monoketals, suggesting new synthetic pathways.
A C6F5OH-catalysed tandem cyclization of ortho-alkynylnaphthols and p-quinone monoketals is disclosed. The C6F5OH catalyst activates alkynylnaphthol to generate all-carbon tetrasubstituted VQM by nucleophilic addition to quinone monoketal (Michael addition). Furthermore,...
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Begum et al. (2025) studied this question.
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