Toxicological and hygienic assessment of the new fungicide fluoxapiproline (literature review)

Fluoxapiproline is a new active substance of pesticides from the chemical class of piperidinyle thiazole isoxazoline. Fluoxapiproline demonstrates biological activity against plant pathogenic oomycetes with mechanisms of action involving oxysterol binding protein inhibition. It is proposed to control late blight in tomato and potato, downy mildew in onions and grapes crops. Aim. Generalization and analysis of data on the toxic and hygienic properties of fluoxapiproline. Materials and Methods. Systematization and evaluation of scientific literature according to the PubMed and Google Scholar databases. Results. Results of our analysis of literature data showed that in according to accepted in Ukraine approaches (the Hygienic classification of pesticides by hazard) fluoxapiproline belongs to the pesticides of hazard class 4 (acute oral and dermal toxicity, primary skin irritation, sensitization effect, mutagenicity, carcinogenicity and reproductive toxicity). to pesticides hazard class 3 (primary eye irritation), to pesticides hazard class 2 (acute inhalation toxicity). Toxicity class limit for fluoxapiproline – 2. Fluoxapiproline (repeated dose toxicity: rats, mice and dogs) has a general toxic effect (by a decrease in feed consumption and body weight gain.). Conclusions. According to stability in water fluoxapiproline belongs to the hazard class 1, stability in soil to the pesticides hazard class 2. Based on the conducted research, the health standards of fluoxapiproline (maximum residue limits (MRLs) preharvest interval (PHI) etc.) for safety use in Ukraine will be set and recommended.