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August 18, 2025The Annual Review of Pharmacology and Toxicology

Dengue Fever Vaccines: Progress and Challenges

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Authors

ARAlan L. RothmanHFHeather Friberg

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Overview

Progress on dengue vaccines shows promise, yet immune challenges complicate broad use in populations.

Key Points

  • Despite advancements, no broadly suitable dengue vaccine has been identified yet, complicating disease management.
  • The completion of Phase III trials marks significant achievements, but obstacles remain due to multiple dengue viral serotypes.
  • Immune imprinting and enhancement of infection pose major challenges to effective vaccination strategies.
  • Future clinical research is essential for understanding dengue virus infections and improving vaccine efficacy.

Cite This Study

Rothman et al. (2025) studied this question.

synapsesocial.com/papers/68af475aad7bf08b1ead43b3https://doi.org/10.1146/annurev-pharmtox-062124-040711
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