This method improves regioselective trichloromethyl alcohol synthesis from alkenes, suggesting a sustainable approach for synthetic transformations.
A visible light‐driven, metal‐free strategy for the regioselective synthesis of β‐trichloromethyl alcohols has been developed through a three‐component reaction of alkenes with CCl 4 and TBHP under mild blue LED irradiation. This method achieves vicinal trichloromethyl hydroxylation with broad substrate scope and good functional group tolerance. Mechanistic studies revealed a radical pathway in which TBHP acts as the hydroxyl donor. The protocol operates under ambient conditions without transition metals, offering a sustainable and scalable platform for synthesizing polyhalogenated building blocks with potential applications in medicinal chemistry and synthetic transformations.
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Jiang et al. (2025) studied this question.
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