This analysis identifies adverse covariates affecting relapse-free survival in NPM1-mutated AML patients, suggesting intensive therapy may be needed.
Key Points
Poor relapse-free survival is associated with factors like male sex, WBC count ≥19 × 10^9/L, and MRD positivity.
For NPM1 mut/FLT3-ITDwt patients, the classification into low-risk, intermediate-risk, and high-risk shows significant differences in survival outcomes.
NPM1 mut/FLT3-ITDmut patients without allogeneic transplantation exhibit factors such as FLT3-ITD mutation linked to poor prognosis.
High-risk patients may require more intensive therapies based on identified prognostic covariates.