Liquid Phase Biological Electron Microscopy: Many Published Results and Claimed Benefits Are Fantasy, Not Fact

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Many claims of high-resolution imaging of macromolecular machines are unsupported and misled.
Analysis of publicly-available EM images shows evidence of drying, contrary to claims of liquid phase imaging.
Fundamental issues like radiation-inactivation and Brownian motion hamper resolution in liquid phase electron microscopy.
Findings highlight that scrutinizing published results is crucial for understanding the technology's limitations.

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Analysis reveals misconceptions about imaging macromolecular machines in liquid, indicating limits of electron microscopy.

Glaeser et al. (2025) studied this question.

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