Evaluation of Hepatotoxicity and Nephrotoxicity of Fenitrothion on Ultrastructural, Immunohistochemical, Histopathological, and Biochemical Changes: Protective Role of Gallic Acid

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Assessment of hepatotoxicity and nephrotoxicity in rats shows that gallic acid can mitigate organ damage from fenitrothion exposure.

Gallic acid supplementation improved liver and kidney function markers, reducing toxicity from fenitrothion exposure.
After 28 days, fenitrothion elevated blood urea nitrogen and creatinine while impairing hepatic markers of liver function.
Observational analysis employed ultrastructural, immunohistochemical, and histopathological evaluations to assess tissue changes.
Findings suggest that gallic acid could serve as a protective agent against fenitrothion-induced liver and kidney damage.

Apaydın et al. (2025) studied this question.

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