Introduction: Guna Siddhanta is a core concept in Ayurveda that explains the pathogenesis of diseases by analyzing the properties (Gunas) of Doshas and Dushyas. Understanding the etiology of Pitta Gulma requires a detailed exploration of this concept, especially in terms of how it applies to the stages of disease development, from causative factors to full manifestation. Methods: This conceptual paper utilizes Guna Siddhanta to map the pathophysiology of Pitta Gulma. The process begins with the underlying condition of Vriddha Vata in Mahasrotas, often resulting from conditions like Jwara, Atisaara, Vamana, or Virechana. The intake of Pitta-aggravating foods (Pittakara Nidanas) triggers an imbalance, leading to a Prakupita (aggravated) Pitta. This Pitta, together with the already vitiated Vata, moves to the Amashaya, causing various clinical manifestations. Results: The manifestation of Pitta Gulma can be explained through Guna Siddhanta and Vikara Vighata Bhava, which clarifies the interaction between Nidana Vishesha, Dosha Vishesha, and Dushya Vishesha. Symptoms like specific pain (Dhupana, Dhuyana) in the Kantha and Ura regions, along with skin discoloration (Harita Haridra Varna), are observed. These clinical signs reflect the impact of aggravated Pitta and Vata in the body. Discussion: The paper highlights the application of Guna Siddhanta in understanding the causal factors and interactions responsible for Pitta Gulma. The framework of Vikara Vighata Bhava helps delineate the relationship between the causative factors and the resulting disease manifestation. Conclusion: This conceptual model provides an in-depth understanding of Pitta Gulma's etiology, offering new insights into Ayurvedic disease pathogenesis through Guna Siddhanta.
B.S. et al. (Fri,) studied this question.