Combination of time-restricted feeding and exercise improves glycaemic control and liver health in male and female mice, suggesting effective strategies against obesity.
Key Points
Combination of time-restricted feeding and exercise reduces weight gain and improves metabolic health in C57BL/6J mice.
Significant benefits were observed in hepatic metabolism, especially in hepatic triglycerides and glucose levels in males and females.
In the study, both TRF and exercise improved insulin sensitivity, liver composition, and reduced inflammatory genes in mice.
Sex-specific differences were noted, highlighting that males had superior aerobic performance and metabolic improvements from combined interventions.