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March 27, 2026Scientific ReportsOpen Access

Exercise and time-restricted and/or dietary feeding jointly improve hepatic lipid homeostasis in diet-induced obese mice

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Authors

NGNicole Power GuerraABAnja U. BräuerMGMarkus H. Gräler

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Overview

Research shows that combined exercise and diet improve liver function in obese mice, suggesting effective strategies for metabolic health.

Key Points

  • This research aims to explore the individual and combined effects of exercise, low-fat diet, and time-restricted feeding on liver health in obese mice.
  • Examined effects of low-fat diet (LFD), treadmill (TM) exercise, and time-restricted feeding (TRF) in diet-induced obese mice.
  • Analyzed comprehensive hepatic lipid composition and related gene expression.
  • Compared individual vs. combined intervention effects on liver function.
  • LFD led to the greatest weight loss and normalized key liver enzyme levels (AST, ALT).
  • Combined TM and TRF reduced liver damage markers under high-fat diet (HFD) conditions.
  • LFD with TRF and/or TM decreased lipogenic gene expression, while certain genes were upregulated in combined groups.
  • Lipidomics revealed increased sphingomyelin and phosphatidylcholine levels with LFD interventions.

Cite This Study

Guerra et al. (2026) studied this question.

synapsesocial.com/papers/69c61ff615a0a509bde18520https://doi.org/10.1038/s41598-026-45394-4
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Exercise Combined with Dietary Switch Improves MASLD by Suppressing Hepatic MOGAT1 and Modulating Metabolic Stress Pathways in HFD-Fed Mice2026
  2. 2Lipidomic Analysis of Liver and Adipose Tissue in a High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease Mice Model Reveals Alterations in Lipid Metabolism by Weight Loss and Aerobic Exercise2024 · 12 citations
  3. 3Time‐restricted feeding combined with exercise improves hepatic and glycaemic metabolism in obese mice: A sex‐dependent study2025 · 6 citations
  4. 4Mechanistic insights and evidence-based management of metabolic dysfunction-associated steatotic liver disease (MASLD; formerly NAFLD) through combined diet and exercise interventions: an evidence-based narrative review2026
  5. 5Effects of Mediterranean diet, exercise, and their combination on body composition and liver outcomes in metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis of randomized controlled trials2025 · 28 citations