Analysis reveals how anoikis influences prognosis and therapeutic response in renal cell carcinoma, suggesting pathways for targeted therapy.
Background Metastasis represents the primary cause of cancer-related mortality, with a high incidence observed in renal cell carcinoma (RCC). Anoikis, a specialized form of apoptosis, plays a crucial role in preventing displaced cells from adhering to new extracellular matrices (ECM), thus inhibiting their aberrant growth. Notably, cancer cells, especially metastatic ones, exhibit resistance to anoikis. However, the exact mechanisms of anoikis resistance in RCC are not well understood.
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Zhou et al. (2025) studied this question.
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