Research reveals low-dose x-ray radiation enhances tumor trafficking of nanoscale coordination polymers via neutrophils, suggesting improved cancer therapy.
Nanoscale coordination polymers (NCPs) have emerged as a promising hybrid platform for drug delivery and cancer therapy. However, their potential in combination with radiotherapy (RT) remains largely unexplored. This study unveils a novel synergy between NCPs and RT, demonstrating a unique neutrophil‐mediated tumor trafficking mechanism. Following X‐ray irradiation, tumors recruit immune cells, particularly circulating neutrophils, which enhance NCP accumulation in the tumor by threefold. Notably, this effect is absent with other nanoparticles and operates independently of the enhanced permeability and retention effect. Immunostimulatory NCPs further leverage this mechanism to reshape the tumor microenvironment, promote immune cell infiltration, and enhance therapeutic efficacy. These findings underscore the potential of integrating NCP‐based nanomedicines with RT to provide a targeted and effective cancer treatment strategy with strong translational promise.
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Tillman et al. (2025) studied this question.
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