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August 20, 2025Iraqi Journal of HematologyOpen Access

Comparative analysis of circular RNA expression in bone marrow and peripheral blood samples of patients with acute myeloid leukemia

Ammar Basim Al-Asadi Jinan Mohammed Jawad Alsaffar

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Key Points

Lower expression of hsa_circ_0001947 was found in bone marrow compared to peripheral blood samples, indicating its potential regulatory role.
In stark contrast, hsa_circ_0009581 showed significantly higher levels in bone marrow, highlighting its importance in AML progression.
This study involved 73 AML patients, with RNA extraction and quantitative analysis performed to understand circRNA roles.
Differential circRNA expression underlines their potential as biomarkers for acute myeloid leukemia diagnosis and monitoring.

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Implication

Analysis shows differences in circular RNA expression in bone marrow and blood of AML patients, suggesting a role in diagnosis and progression.

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Cite This Study

Al-Asadi et al. (2025) studied this question.

synapsesocial.com/papers/68af495fad7bf08b1ead565e https://doi.org/10.4103/ijh.ijh_34_25

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Distinguishing Acute Leukemia Subtypes: The Role of hsa_circ_0012152 and hsa_circ_0020093 in Peripheral Blood2024
2Landscape of circular RNAs in acute myeloid leukemia and their clinical significanceOriginal Research · 2026
3Clinical and functional significance of circular RNAs in cytogenetically normal AMLPrognostic Study · 2020 · 41 citations
4New insights on circ_0002232 and circ-vimentin in acute myeloid leukemia2025
5[Expression and Function of circ_0073585 in Acute Myeloid Leukemia].2024