Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 20, 2025Clinical Chemistry and Laboratory Medicine (CCLM)

Evaluating the performance of a multiparametric IgA assay for celiac disease diagnosis

View Full Paper
Ask AI
Bookmark
Share

Authors

CGCaterina Maria GambinoAOL (United States)LALuisa AgnelloUniversity of PalermoFBFabio Del BenNational Cancer Institute

Discussion

Loading...

Member takes

Implication

Retrospective analysis shows high diagnostic accuracy for IgA markers in celiac disease, indicating a non-invasive option for screening.

Key Points

  • The multiparametric IgA assay demonstrates high diagnostic performance, particularly in untreated celiac disease patients.
  • In the study, the composite score of ≥4 positive markers achieved an AUC of 0.99, indicating excellent diagnostic capability.
  • The assay utilizes a membrane-based enzyme immunoassay method, analyzing IgA antibodies targeting multiple celiac disease-related antigens.
  • This tool may improve celiac disease diagnosis and monitoring, though further validation in larger prospective studies is needed.

Cite This Study

Gambino et al. (2025) studied this question.

synapsesocial.com/papers/68af495fad7bf08b1ead566dhttps://doi.org/10.1515/cclm-2025-0705
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Persistence of elevated deamidated gliadin peptide antibodies on a gluten‐free diet indicates nonresponsive coeliac disease2014 · 30 citations
  2. 2Vitamin and Mineral Deficiencies Are Highly Prevalent in Newly Diagnosed Celiac Disease Patients2013 · 276 citations
  3. 3Diagnosis of Non-Celiac Gluten Sensitivity (NCGS): The Salerno Experts’ Criteria2015 · 577 citations
  4. 4Impact of a Gluten-Free Diet in Adults With Celiac Disease: Nutritional Deficiencies and Challenges2024 · 7 citations
  5. 5Bridging the Gap: Awareness, Knowledge, and Challenges of Living with Celiac Disease in Bulgaria2025 · 5 citations