August 15, 2025Open Access

Multiple distinct metastatic cell states are induced by epithelial-mesenchymal plasticity

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Single-cell RNA sequencing reveals diverse cell states in triple-negative breast cancer, highlighting implications for metastasis.

Metastatic potential is significantly enhanced due to multiple distinct cell states generated by epithelial-mesenchymal plasticity, revealing important dynamics in cancer progression.
The study identified high-plasticity EpCAM-high cells, which exhibit intrinsic plasticity and can give rise to lung metastases independently, indicating their role in cancer severity.
Using single-cell RNA sequencing in a genetically engineered mouse model, researchers mapped phenotypic heterogeneity related to EMP, uncovering critical interactions in tumor biology.
Findings suggest that EMP contributes to the heritable nature of cancer cells, emphasizing the need for targeted therapies against these unique metastatic states.

Alsharief et al. (2025) studied this question.

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