Formulation and Invitro Evaluation of Terbutaline Sulphate Transdermal Patches

In the present work, attempts were made to prepare and evaluate “Terbutaline sulphate transdermal patches”. It acts as controlled and sustained release bronchodilator. Technique used to prepare these polymeric patches is solvent evaporating technique, used various ratios of ethyl cellulose, HPMC, glycol, terbutaline sulphate etc,. From T1-T5 combination with active ingredient, eudragid RL and from T6-T10 ethyl cellulose were used. Require quantity of polymer measure n taken and allow swelling for hours in solvent (which is combination of ethanol and dichloromethane equally) included plasticizer as well. Mixing of polymeric and drug solution followed by spreading on petriplate of surface area about 6.9 cm2 kept for drying followed by vacuum drying for few hours. From the area 6.9 cm2 cut the patches from complete sheet. About 10 patches of terbutaline sulphate were formed from single sheet. All formulations contain different ratios of ingredients. All typical bands occur due to polymer which shows the report as ‘there is no interaction between polymer and drug’. Bands observed through IR spectrolysis.