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August 14, 2025

Sex Differences in Opioid-Related Mortality Trends in the United States, 1999-2020: By Age, Race/Ethnicity, Region, and Opioid Type.

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Authors

RKRafi KhandakerAEAnnika EythGEGreta Muriel Eikermann

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Overview

Analysis reveals sex differences in opioid-related overdose deaths by age and race/ethnicity from 1999 to 2020, highlighting targeted interventions are needed.

Key Points

  • Opioid-related overdose deaths increased overall, with men having a higher mortality burden than women.
  • From 1999 to 2020, there were 564,418 opioid-related overdose deaths, with men experiencing a mortality rate ratio of 2.11.
  • Using retrospective analysis of National Center for Health Statistics data, trends were examined from 1999 to 2020 based on age, race/ethnicity, region, and opioid type.
  • While men showed higher rates, vulnerable groups of women under 45 years and from the Northeast showed increasing mortality trends.

Cite This Study

Khandaker et al. (2025) studied this question.

synapsesocial.com/papers/68af4cd3ad7bf08b1ead5e0ehttps://doi.org/10.1177/15409996251369454
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