August 1, 2025Age and AgeingOpen Access

Longitudinal trajectories of polypharmacy in older people, and their association with the risk of mortality: a joint latent class model analysis of real-world data from the UK and the Netherlands

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Identifying four distinct polypharmacy clusters, the high-decreasing cluster showed the highest mortality risk and chronic comorbidities in older people.
Participants in the intermediate-fast/increasing cluster had the steepest rate of polypharmacy progression and worst survival outcomes, highlighting significant health impacts.
Joint latent class modeling was applied to real-world data from the UK and Netherlands, ensuring robust and generalizable findings across diverse populations.
High baseline and increasing levels of polypharmacy were associated with an elevated risk of mortality in older adults, suggesting the need for careful monitoring.

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Latent class model analysis reveals distinct polypharmacy patterns and associated mortality risks in older people across the UK and Netherlands.

Elhussein et al. (2025) studied this question.

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Latent class model analysis reveals distinct polypharmacy patterns and associated mortality risks in older people across the UK and Netherlands.