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January 1, 2025Open Veterinary JournalOpen Access

Effect of acepromazine or dexmedetomidine associated with methadone on anesthetic induction with propofol at a rate of 1 mg/kg/min in healthy dogs: A randomized clinical trial

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Authors

GSGabriela SenaLGLucas Wamser Fonseca GonzagaPAPablo Avelar

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Overview

Randomized clinical trial shows dexmedetomidine enhances sedation and reduces propofol dose in healthy dogs, suggesting better premedication effects.

Key Points

  • Dexmedetomidine improves sedation scores and reduces propofol requirements compared to acepromazine during induction.
  • Dogs in the dexmedetomidine group had a shorter induction time and fewer incidences of myoclonus than those receiving acepromazine.
  • This randomized clinical trial involved 24 healthy adult dogs comparing two premedication protocols before anesthesia.
  • Significantly, dexmedetomidine impacts heart and respiratory rates post-induction more than acepromazine combined with methadone.

Cite This Study

Sena et al. (2025) studied this question.

synapsesocial.com/papers/68af4cd3ad7bf08b1ead5f14https://doi.org/10.5455/ovj.2025.v15.i7.42
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinico-Physiological and Haemodynamic Alterations Following Propofol Induction and Premedication with Butorphanol, Dexmedetomidine or Acepromazine in Dogs2024 · 1 citations
  2. 2Dexmedetomidine or Butorphanol for Co-Induction of General Anaesthesia with Propofol in Unpremedicated Healthy Dogs: Clinical and Echocardiographic Assessment2025
  3. 3ACEPROMAZINE DOES NOT ENHANCE SEDATION OR REDUCE PROPOFOL REQUIREMENTS WHEN COMBINED WITH DEXMEDETOMIDINE IN DOGS2026
  4. 4Medetomidine-vatinoxan-methadone and acepromazine-methadone: comparison of sedative and cardiovascular properties as a preanaesthetic medication in healthy dogs2025
  5. 5Cardiopulmonary effects of dexmedetomidine-butorphanol premedication, propofoldiazepam induction and isoflurane maintenance anaesthesia for surgical management of acute abdomen in dogs2024