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January 1, 2025Advances in HematologyOpen Access

Real‐World Safety and Efficacy of Venetoclax in Chronic Lymphocytic Leukemia: A Single‐Center Comparative Analysis With Randomized Clinical Trials

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Authors

STSophie ThauZealand University HospitalCPChristian Bjørn PoulsenRoskilde UniversityMLMorten Kranker LarsenZealand University Hospital

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Implication

Real-world analysis shows comparable safety and efficacy of venetoclax in patients with CLL, indicating similar outcomes to trials.

Key Points

  • Both groups exhibited similar efficacy and safety outcomes, demonstrating the effectiveness of venetoclax in real-world settings.
  • Analysis of 112 patients, including 74 in standard care and 38 in trials, confirmed venetoclax's tolerability.
  • Single-center study aligns with findings from major randomized clinical trials, reinforcing venetoclax's safety profile.
  • Real-world patients did not experience significant tumor lysis syndrome, highlighting the drug's manageable risks.

Cite This Study

Thau et al. (2025) studied this question.

synapsesocial.com/papers/68af4cd3ad7bf08b1ead6081https://doi.org/10.1155/ah/3910332
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Tumor Lysis Syndrome2011 · 1,017 citations
  2. 2Tumor lysis syndrome: still the Achilles heel of venetoclax in treatment of CLL?2020 · 3 citations
  3. 3Incidence and risk of tumor lysis syndrome in patients with relapsed chronic lymphocytic leukemia (CLL) treated with venetoclax in routine clinical practice2020 · 23 citations
  4. 4PB1938: REAL WORLD EFFECTIVENESS AND SAFETY OF VENETOCLAX IN COMBINATION WITH OBINUTUZUMAB IN TREATMENT NAIVE CLL PATIENTS – DATA FROM THE OBSERVATIONAL STUDY VERVE2023 · 4 citations
  5. 5Real-world evidence of obinutuzumab and venetoclax in previously treated patients with chronic lymphocytic leukemia or small lymphocytic lymphoma2024 · 18 citations