What type of study is this?

This is a In Vitro Study study.

August 19, 2025Open Access

Monoclonal Antibodies from COVID-19 Convalescent Patients Target Cryptic Epitopes for Universal SARS-CoV-2 Neutralization

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Analysis identifies novel epitopes for two monoclonal antibodies in convalescent patients, suggesting broader COVID-19 immunity.

These antibodies demonstrate broad neutralizing activity against all circulating variants of concern, including Omicron.
Monoclonal antibodies TAU-1109 and TAU-2310 target conserved cryptic epitopes, essential for enhanced neutralization.
The structural analysis unveils the destabilization of spike trimers, inhibiting viral entry into host cells.
This work paves the way for developing universal therapeutic antibodies and vaccines against SARS-CoV-2.

Harit et al. (2025) studied this question.

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