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August 19, 2025ACS NanoOpen Access

Economical and Versatile Subunit Design Principles for Self-Assembled DNA Origami Structures

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Authors

WWWei-Shao WeiTVThomas E. VidebækDHDaichi Hayakawa

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Overview

Modular design approach enables precise targeting of self-assembled structures, suggesting flexibility enhances assembly accuracy.

Key Points

  • This design enhances the range of self-assembled DNA origami structures, including shells and tubes.
  • Demonstrated assembly includes structures of varying Gaussian curvature, showcasing adaptability and precision.
  • Leveraging cryogenic electron microscopy helped characterize angle modules' mechanical properties and roles.
  • Incorporating flexible bonds increases error tolerance, allowing for more complex configurations while retaining target fidelity.

Cite This Study

Wei et al. (2025) studied this question.

synapsesocial.com/papers/68af4cd8ad7bf08b1ead6100https://doi.org/10.1021/acsnano.5c06681
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