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August 1, 2025JCO Precision Oncology

Comprehensive Screening for Early Cancer Detection in Individuals With Genetic Predisposition

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Authors

НБН. А. БодуноваABAirat BilyalovADA. M. Danishevich

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Overview

Observational analysis reveals early cancer detection through screening in individuals with genetic predisposition, suggesting improved outcomes.

Key Points

  • The comprehensive screening program successfully identified 10.2% of early-stage cancers in healthy individuals with pathogenic variants.
  • In participants diagnosed through screening, 96.4% of detected cancers were stage I to II, highlighting effective early diagnosis.
  • This analysis included 816 participants, comparing outcomes of healthy P/LP variant carriers and cancer patients.
  • Findings indicate that tailored screening enhances early detection of high-risk cancers, potentially improving treatment.

Cite This Study

Бодунова et al. (2025) studied this question.

synapsesocial.com/papers/68af4cd8ad7bf08b1ead645dhttps://doi.org/10.1200/po-25-00333
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