Case report reveals penile mass linked to metastatic prostate adenocarcinoma in 72-year-old, suggesting a need for awareness of atypical presentations.
Metastatic prostate adenocarcinoma presenting as a penile lesion is extremely rare and can mimic primary penile malignancies. A 72-year-old male presented with acute urinary retention and a painless penile lesion with phimosis. The lesion had gradually enlarged over six months with intermittent bleeding. Examination revealed a 3 cm ulcerated mass on the glans near the coronal sulcus. A wedge biopsy suggested adenosquamous carcinoma. CT showed no distant metastases. The patient underwent total penectomy with perineal urethrostomy. Histopathology revealed malignancy with clear margins. Further evaluation at a major tertiary health care centre, including immunohistochemistry, confirmed metastatic prostatic adenocarcinoma (NKX3.1, PSA positive; CK7, CK20, CDX2 negative). Serum prostate-specific antigen (PSA) was elevated (37.8 ng/mL), and prostate-specific membrane antigen positron emission tomography (PSMA PET) confirmed metastasis. The patient was treated with androgen deprivation therapy (bilateral orchidectomy), abiraterone, and docetaxel.
No takes yet. Share an insight, caveat, or question.
Koushik et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: