Multi-component approach to 2-aminofurans, furo[2,3-b]pyridines, and furo[2,3-d]pyrimidines containing imidazole moiety

Ekaterina S. Uvarova; Антон В. Кутасевич; Tatiana Yu. Koldaeva; Vitaly S. Mityanov

doi:10.1039/d5ob01230a

January 1, 2025Organic & Biomolecular Chemistry

Multi-component approach to 2-aminofurans, furo[2,3-b]pyridines, and furo[2,3-d]pyrimidines containing imidazole moiety

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Key Points

The synthesis produced 2-aminofurans effectively, integrating the imidazole moiety into the compounds.
The most significant outcome involved using a three-component condensation involving specific reactants.
The method utilizes 2-unsubstituted imidazole N-oxides combined with arylglyoxals and 3-ketonitriles for the synthesis.
This approach suggests new pathways for creating imidazole-containing compounds with potential applications.

Implication

This methodology demonstrates an innovative synthesis of 2-aminofurans in a three-component reaction, highlighting imidazole's role in creating diverse compounds.

Abstract

A methodology for the synthesis of 2-aminofurans containing an imidazole substituent has been developed. The method is based on a three-component condensation of 2-unsubstituted imidazole N-oxides, arylglyoxals, and 3-ketonitriles. The...

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Uvarova et al. (2025) studied this question.

synapsesocial.com/papers/68af4ce5ad7bf08b1ead6bd9 https://doi.org/10.1039/d5ob01230a

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Multi-component approach to 2-aminofurans, furo[2,3-b]pyridines, and furo[2,3-d]pyrimidines containing imidazole moiety

Key Points

Implication

Abstract

Discussion

Cite This Study

Multi-component approach to 2-aminofurans, furo[2,3-b]pyridines, and furo[2,3-d]pyrimidines containing imidazole moiety

Key Points

Implication

Abstract

Discussion

Cite This Study

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