Effects of Cervi Penis Wine on Bone Mineral Density and Lipid of Ovariectomized Female Rats

Objective To explore the effects of Cervi penis wine on bone mineral density and lipid of ovariectomized female Sprague Dawley (SD) rats. Methods Fifty female SD rats were randomly divided into five groups: normal control group, osteoporosis model group, low dose of Cervi penis wine intervention group, medium dose of Cervi penis wine intervention group and high dose of Cervi penis wine intervention group. Normal control group and osteoporosis model group were given saline with the dose of 4ml/d. The doses of Cervi penis wine were 2，4 and 6ml/d respectively in low, medium and high dose of Cervi penis wine intervention group. After the feeding of Cervi penis wine for 30 days, the bone mineral density and lipid of rats were assessed. Results The difference in bone mineral density among the three doses of Cervi penis wine intervention groups was significant (P ＜ 0.05); the most obvious improvement of one mineral density was found in low and medium dose of Cervi penis wine groups (P ＜ 0.05). The TG、TC and LDL-C significantly decreased, and HDL-C increased significantly in Cervi penis wine group compared with those in the osteoporosis model group (P ＜ 0.05). The most obvious improvement was found in low and medium dose of Cervi penis wine groups (P ＜ 0.05). Conclusions Tree different doses of Cervi penis wine could prevent BMD reducing and the osteoporosis，and Cervi penis wine could improve the lipid metabolism. The effects of low and medium dose of groups were more obvious.