What type of study is this?

This is a Animal Study study (also classified as: Observational).

August 20, 2025Frontiers in ImmunologyOpen Access

Assessing the impact of TET2 and TET3 deletion in TCRalpha and TCRbeta repertoire in murine CD4 T cells in physiological and pathophysiological conditions

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Analysis shows TCR repertoire diversity reduction in Tet2/3 DKO CD4 T cells, suggesting potential impacts on T cell function.

Tet2/3 DKO CD4 T cells exhibit an oligoclonal TCR repertoire, indicating reduced diversity after transplantation.
TCR sequencing data reveal that both wild type and Tet2/3 DKO CD4 cells are polyclonal in the thymus and spleen.
Analysis emphasizes the role of TET proteins in shaping TCRalpha and TCRbeta repertoires in CD4 T cells.
Findings may provide insights into T cell responses in physiological and pathophysiological conditions.

Äijö et al. (2025) studied this question.

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