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August 19, 2025Molecular Carcinogenesis

Independent Clonal Origin in Early‐Stage Bilateral Papillary Thyroid Cancer: Evidence From Nuclear and Mitochondrial Genome Analysis

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Authors

XSXingyun SuJYJimeng YuanXCXianmeng Chen

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Overview

Analysis of genetic alterations in bilateral papillary thyroid cancer suggests independent malignant origins, highlighting clinical implications.

Key Points

  • Most early-stage bilateral papillary thyroid cancers involve distinct malignant clones, indicating independent origins.
  • A total of 48 mutations were identified in the nuclear genome, with the BRAF V600E mutation being the most common.
  • Comprehensive sequencing was conducted on pairs of bilateral tumors using a specialized cancer-gene panel and mitochondrial DNA.
  • Findings emphasize the need for personalized treatment approaches, given the discordant genetic alterations in most cases.

Cite This Study

Su et al. (2025) studied this question.

synapsesocial.com/papers/68af4eaead7bf08b1ead7369https://doi.org/10.1002/mc.70031
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