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August 20, 2025The British Journal of PsychiatryOpen Access

Transdiagnostic efficacy of lurasidone on depressive symptoms: systematic review and meta-analysis of randomised controlled trials

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Authors

AGAna GhenciulescuAPAnna PearseAMAmedeo Minichino

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Overview

Systematic review shows lurasidone improves depressive symptoms across diagnoses, indicating high acceptability and safety.

Key Points

  • Lurasidone significantly improves depressive symptoms across various psychiatric diagnoses, indicating broad efficacy.
  • Pooled analysis of 5239 participants revealed a standardised mean difference of −0.26 after treatment with lurasidone compared to placebo.
  • The systematic review and meta-analysis assessed 14 trials, employing the Cochrane risk of bias tool to evaluate study quality.
  • Challenges include high risk of bias in included studies and substantial heterogeneity, highlighting the need for further research.

Cite This Study

Ghenciulescu et al. (2025) studied this question.

synapsesocial.com/papers/68af4eb4ad7bf08b1ead75c3https://doi.org/10.1192/bjp.2025.10343
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