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September 5, 20250 citationsOpen Access

Effectiveness of Lurasidone in Augmenting Treatment-Resistant Bipolar Depression Outcomes

Real-World Outcomes of Lurasidone Augmentation for Treatment-Resistant Bipolar Depression: A Retrospective Observational Analysis

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Authors

GPGiorgia PorcedduEPEnrico PessinaCCC Cattaneo

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Overview

Observational analysis found lurasidone improves symptoms in treatment-resistant bipolar depression, suggesting potential for personalized interventions.

Key Points

  • Lurasidone leads to significant symptom improvements in treatment-resistant bipolar depression, but remission was low.
  • Clinical response was achieved in 33.3% of participants treated with an average dose of 39.8 mg/day of lurasidone.
  • This retrospective observational analysis monitored patients over four weeks, assessing multiple symptom severity scales.
  • Findings indicate lurasidone may enhance individualized treatment strategies, but further research is needed to solidify its role.

Cite This Study

Porceddu et al. (2025) studied this question.

synapsesocial.com/papers/68bb46c96d6d5674bccff0ebhttps://doi.org/10.20944/preprints202508.2153.v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lurasidone and risk of metabolic syndrome: results from short and long-term studies in patients with bipolar depression2023 · 5 citations
  2. 2Transdiagnostic efficacy of lurasidone on depressive symptoms: systematic review and meta-analysis of randomised controlled trials2025 · 2 citations
  3. 3Efficacy and Safety of Adding Lurasidone to Ongoing Therapy With Lithium or Valproate for the Treatment of an Acute Bipolar Depressive Episode2024 · 2 citations
  4. 4648. A RANDOMIZED DOUBLE BLIND PLACEBO CONTROLLED TRIAL OF LURASIDONE IN IMPROVING COGNITIVE IMPAIRMENT IN EUTHYMIC PATIENTS WITH BIPOLAR DISORDER2025
  5. 5Long-term safety and effectiveness of lurasidone in adolescents and young adults with schizophrenia: pooled post hoc analyses of two 12-month extension studies2024 · 3 citations