Design, synthesis, and cytotoxic evaluation of quinazoline-based derivatives as VEGER-2 inhibitors: comparative study against EGFR kinase activity, induction of apoptosis, and molecular docking study

Reda R. Mabrouk; Arafa Musa; Maged Mohammed Saleh Al Ward; Shaimaa Hussein; Ahmed K. B. Aljohani; Mohamed Ayman El‐Zahabi; Alaa Elwan

doi:10.1039/d5ra03829d

January 1, 2025RSC AdvancesOpen Access

Design, synthesis, and cytotoxic evaluation of quinazoline-based derivatives as VEGER-2 inhibitors: comparative study against EGFR kinase activity, induction of apoptosis, and molecular docking study

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Key Points

Quinazoline-based compounds exhibit cytotoxic properties, leading to potential therapeutic applications.
Comparative analysis shows effectiveness against both VEGFR-2 and EGFR kinase activities.
Molecular docking studies confirm the binding affinity of the synthesized compounds to VEGFR-2.
Results suggest these quinazoline derivatives may enhance cancer treatment strategies, calling for further investigation.

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Implication

Novel quinazoline derivatives demonstrate cytotoxic effects and apoptosis induction in comparison to EGFR kinase activity, highlighting potential therapeutic uses.

Abstract

A novel series of quinazoline-based compounds were designed and synthesized as modified analogues to certain known VEGFR-2 inhibitors, as an extension of our work on the design and synthesis of new VEGFR-2 inhibitors.

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Mabrouk et al. (2025) studied this question.

synapsesocial.com/papers/68af4ec0ad7bf08b1ead7ca3 https://doi.org/10.1039/d5ra03829d

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Design, synthesis, and cytotoxic evaluation of quinazoline-based derivatives as VEGER-2 inhibitors: comparative study against EGFR kinase activity, induction of apoptosis, and molecular docking study

Key Points

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Implication

Abstract

Discussion

Cite This Study

Design, synthesis, and cytotoxic evaluation of quinazoline-based derivatives as VEGER-2 inhibitors: comparative study against EGFR kinase activity, induction of apoptosis, and molecular docking study

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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