Asymmetric total synthesis of (+)-fusariumin and (+)-sporotricale methyl ether: Exploration of Cu(I) catalysed regiodivergent cascade cyclization strategy

Samik Nanda; Swagata Das; Ananta Karmakar

doi:10.1039/d5ob01245g

January 1, 2025Organic & Biomolecular Chemistry

Asymmetric total synthesis of (+)-fusariumin and (+)-sporotricale methyl ether: Exploration of Cu(I) catalysed regiodivergent cascade cyclization strategy

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Key Points

The synthesis of (+)-fusariumin was achieved through a Cu(I) catalyzed cyclization, establishing a new method for its production.
Key process involved is a 6-endo-dig cyclization, crucial to the successful synthesis of isocoumarin-based compounds.
The approach also targets the phthalide-based natural product sporotricale, highlighting its versatility in natural product synthesis.
This novel strategy may enable further exploration of other natural products, expanding potential applications in organic synthesis.

Implication

Asymmetric total synthesis of the natural products fusariumin and sporotricale demonstrates regiodivergent cascade cyclization using Cu(I) catalysis.

Abstract

Asymmetric total synthesis of isocoumarin-based natural product (+)-fusariumin was achieved for the first time through Cu(I) catalysed 6-endo-dig cyclization as a key step. Synthesis of phthalide-based natural product sporotricale methyl...

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Cite This Study

Nanda et al. (2025) studied this question.

synapsesocial.com/papers/68af4ec0ad7bf08b1ead7d1c https://doi.org/10.1039/d5ob01245g

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Asymmetric total synthesis of (+)-fusariumin and (+)-sporotricale methyl ether: Exploration of Cu(I) catalysed regiodivergent cascade cyclization strategy

Key Points

Implication

Abstract

Discussion

Cite This Study

Asymmetric total synthesis of (+)-fusariumin and (+)-sporotricale methyl ether: Exploration of Cu(I) catalysed regiodivergent cascade cyclization strategy

Key Points

Implication

Abstract

Discussion

Cite This Study

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