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August 20, 2025CancersOpen Access

A Comprehensive Genomic Analysis of Nucleophosmin (NPM1) in Acute Myeloid Leukemia

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NPM1-mutated AML shows more genomic alterations compared to wild-type AML, suggesting a unique profile.
Among 4206 AML cases, 15.1% exhibited NPM1 genomic alterations, predominantly in females aged 62.
Methods included comprehensive DNA and RNA sequencing across multiple cohorts yielding distinct mutation profiles.
Therapy-related mutations in AML appear more frequently in NPM1-mutated cases, impacting treatment strategies.

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Comprehensive genomic study reveals distinct mutations in NPM1-mutated and wild-type AML, indicating response variations.

Batayneh et al. (2025) studied this question.

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