Cycloisomerization creates tetracyclic quinolinone derivatives, suggesting efficient synthesis for polycyclic compounds.
A novel palladium-catalyzed cycloisomerization of bicyclobutyl amides has been developed for the expedited construction of polycyclic quinolinone skeletons. The reaction proceeded well to furnish a variety of tetracyclic quinolinone derivatives in good yields. Additionally, scale-up reactions and derivatization of tetracyclic quinolinones were demonstrated as well.
No takes yet. Share an insight, caveat, or question.
Wang et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: