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August 21, 2025Open Access

Oral liposomal iron vs. oral iron polymaltose in CKD children with iron deficiency anemia: a cross-over study

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Authors

HSHappy SawiresEAEman M. AbdelazimFAFatma M. Atia

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Overview

Cross-over study shows no significant difference in iron levels in CKD children with anemia, highlighting adverse effects and therapies' profiles.

Key Points

  • Only 14% of children treated with iron polymaltose saw anemia resolution, while 18% improved with liposomal iron, indicating low efficacy.
  • Iron polymaltose reduced serum phosphorus in a significant manner (p = 0.047), suggesting potential benefits in bone mineral management.
  • Cross-over study used involves 40 CKD children with absolute iron deficiency anemia, assessed over a 3-month treatment period.
  • Liposomal iron displayed a much lower rate of adverse effects (15%) compared to iron polymaltose (70%), supporting its safer profile.

Cite This Study

Sawires et al. (2025) studied this question.

synapsesocial.com/papers/68af4ec6ad7bf08b1ead803dhttps://doi.org/10.21203/rs.3.rs-7329929/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Oral liposomal iron vs. oral iron polymaltose in children with chronic kidney disease iron deficiency anemia: a cross-over study2026 · 1 citations
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  5. 5Efficacy and Safety of Oral Supplementation with Liposomal Iron in Non-Dialysis Chronic Kidney Disease Patients with Iron Deficiency2024 · 7 citations