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August 21, 2025Brain CommunicationsOpen Access

Detection of cognitive deficits years prior to clinical diagnosis across neurological conditions

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Authors

XTXin You TaiNuffield Orthopaedic Centre STSofia TonioloNuffield Orthopaedic Centre DLDavid J LlewellynTuring Institute

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Implication

Analysis reveals cognitive deficits years before diagnosis in conditions like schizophrenia and Parkinson's disease, suggesting specific trajectories for each disease.

Key Points

Cognitive deficits appear years before clinical diagnosis, highlighting early signs of neurological diseases.
At 7.4 years prior to diagnosis, executive function was lower for multiple sclerosis and focal epilepsy compared to controls.
Using data from 497,252 participants, differences in cognitive trajectory were observed across several neurological conditions.
Understanding these cognitive trajectories may improve early identification and risk management for neurological diseases.

Cite This Study

Tai et al. (2025) studied this question.

synapsesocial.com/papers/68af4ec6ad7bf08b1ead8171 https://doi.org/10.1093/braincomms/fcaf307

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Implication

Analysis reveals cognitive deficits years before diagnosis in conditions like schizophrenia and Parkinson's disease, suggesting specific trajectories for each disease.

Detection of cognitive deficits years prior to clinical diagnosis across neurological conditions

Discussion

Member takes

Implication

Key Points

Cite This Study

Detection of cognitive deficits years prior to clinical diagnosis across neurological conditions

Discussion

Member takes

Implication

Key Points

Cite This Study

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