What type of study is this?

This is a Observational study (also classified as: Animal Study, In Vitro Study).

August 21, 2025Stem Cells

Human Obesity Decreases the Anti-inflammatory Functionality of Adipose Tissue-Derived Mesenchymal Stem/Stomal Cells by Upregulating IL-1β Expression.

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Analysis reveals obesity alters anti-inflammatory properties in mesenchymal stem cells, suggesting IL-1β as a therapeutic target.

Obesity decreases the anti-inflammatory functionality of adipose-derived stem cells, impacting health.
Two thousand eighty-seven 5hmC modifications and 175 mRNA changes were found in MSCs from obese patients.
Injection of obese MSCs increased IL-1β and M1 macrophages while reducing kidney perfusion.
Targeting IL-1β may help restore stem cell functionality affected by obesity.

Xing et al. (2025) studied this question.

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August 21, 2025Stem Cells

View Full Paper

Ask AI

Bookmark

Authors

Analysis reveals obesity alters anti-inflammatory properties in mesenchymal stem cells, suggesting IL-1β as a therapeutic target.

Obesity decreases the anti-inflammatory functionality of adipose-derived stem cells, impacting health.
Two thousand eighty-seven 5hmC modifications and 175 mRNA changes were found in MSCs from obese patients.
Injection of obese MSCs increased IL-1β and M1 macrophages while reducing kidney perfusion.
Targeting IL-1β may help restore stem cell functionality affected by obesity.

Xing et al. (2025) studied this question.

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