Why the study?
The incidence of obesity and diabetes is rising without optimal management, and obesity-associated type 2 diabetes causes adipose inflammation, oxidative stress, white fat hyperplasia, and mitochondrial dysfunction.
Does intraperitoneal delivery of antioxidant-upregulated MSCs improve fatty liver disease, systemic inflammation, and glucose tolerance in diet-induced obese mice?
Population
Diet-induced obese mouse models fed a 45% or 60% high-fat diet
Comparison
Sod2- or catalase-upregulated human adipose-derived MSCs vs null-control MSCs
Design
Animal experimental study
Follow-up
4 weeks
Authors
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Antioxidant-upregulated MSC delivery may ease oxidative stress in obese diabetic models; leaves open clinical translation for glucose tolerance.
Does intraperitoneal delivery of antioxidant-upregulated MSCs improve fatty liver disease, systemic inflammation, and glucose tolerance in diet-induced obese mice?
Antioxidant-upregulated mesenchymal stem cell delivery reduces liver fat accumulation and systemic inflammation while improving glucose tolerance in diet-induced obese mice.
Domingues et al. (2019) studied this question.
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