Why the study?
Does a single intravenous infusion of syngeneic ASCs improve glucose homeostasis in a high-fat diet-induced obese mouse model?
Population
C57BL/6 mice fed a high-fat diet for 20 weeks to generate the diet-induced obese (DIO) mouse model.
Comparison
Single intravenous infusion of ex vivo expanded… vs DIO or CHOW mice injected with saline.
Design
Preclinical
Follow-up
6 weeks
Key result
A single intravenous infusion of syngeneic adipose-derived mesenchymal stem cells significantly reduced blood glucose levels and improved glucose tolerance in high-fat diet-induced obese mice.
Authors
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ASC infusion improves glucose control in obese mice; leaves open translation to human metabolic disease.
Does a single intravenous infusion of syngeneic ASCs improve glucose homeostasis in a high-fat diet-induced obese mouse model?
p-value: p=<0.05
A single intravenous infusion of adipose-derived mesenchymal stem cells improves glucose homeostasis, reduces inflammation, and preserves pancreatic beta-cell mass in a mouse model of diet-induced obesity.
Cao et al. (2015) studied Diet-induced obesity and insulin resistance (n=51). Syngeneic adipose-derived mesenchymal stem cells (ASCs) vs. Saline injection was evaluated on Blood glucose levels and glucose tolerance (p=<0.05). A single intravenous infusion of syngeneic adipose-derived mesenchymal stem cells significantly reduced blood glucose levels and improved glucose tolerance in high-fat diet-induced obese mice.