PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
Synapse
⌘+K
Synapse
December 1, 2015Stem Cell Research & TherapyOpen Access

Genetic modification of human mesenchymal stem cells helps to reduce adiposity and improve glucose tolerance in an obese diabetic mouse model

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does intraperitoneal delivery of SOD2-upregulated mesenchymal stem cells improve glucose tolerance and reduce adiposity in obese diabetic mice?

Population

Human adipose tissue-derived and bone marrow-derived mesenchymal stem cells; obese diabetic mice.

Comparison

Intraperitoneal delivery of 1.5 million human… vs Intraperitoneal delivery of human mesenchymal…

Design

Preclinical

Follow-up

4 weeks

Authors

SSSabyasachi SenCDCleyton C. DominguesCRCarol Rouphael

Discussion

Loading...

Member takes

Overview

Hypothesis-generating in obese diabetic mice; leaves open clinical translation of SOD2-MSCs.

Structured PICO

Does intraperitoneal delivery of SOD2-upregulated mesenchymal stem cells improve glucose tolerance and reduce adiposity in obese diabetic mice?

P
Population
Human adipose tissue-derived and bone marrow-derived mesenchymal stem cells (in vitro); obese diabetic (db/db) mice (n=15 for in vivo experiment).
I
Intervention
Intraperitoneal delivery of 1.5 million human mesenchymal stem cells transduced with AdSOD2 (superoxide dismutase 2) suspended in 200 uL of PBS.
C
Comparator
Intraperitoneal delivery of human mesenchymal stem cells transduced with AdGFP (control) or saline.
O
Outcome
Glucose tolerance, body weight, and body composition (fat mass) at 4 weeks post-transplantation.surrogate

Delivery of superoxide dismutase (SOD2) using mesenchymal stem cells as a gene delivery vehicle reduces inflammation, body weight, and improves glucose tolerance in a diabetic mouse model.

Cite This Study

Sen et al. (2015) studied this question.

synapsesocial.com/papers/6a80b6134fef96f46ad4b555https://doi.org/10.1186/s13287-015-0224-9
View Full Paper
Ask AI
Bookmark
Share