Exogenous mitochondrial pretreatment improves therapeutic effects of UC‐MSCs on NAFLD in diabetic mice, suggesting a novel intervention.
Key Points
Exogenous mitochondrial pretreatment significantly lowers blood glucose and triglyceride levels in diabetic mice, improving liver function and health.
During the study, mitochondrial transfer to liver cells was enhanced, contributing to better metabolic outcomes and less liver damage as measured by histopathology.
Treatment involved mitochondrial pretreatment of umbilical cord‐derived MSCs, followed by weekly infusions into type 2 diabetic mice over a month.
This approach highlights the potential for improved stem cell therapy targeting diabetes-related liver disease by enhancing mitochondrial function in affected tissues.