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August 15, 2025Open Access

Figure S1 from Reactivating cGAS–STING Signaling by Targeting SOS1 Enhances Antitumor Immunity in NRAS-Mutant Tumors

Jia‐Lu Shan Kai-Ming Zhang Wen-Qing Zhong Xiao-Yu Yang Zhi‐Ling Li Yun Huang Tian Du Dong Yang Jia‐Hong Tang Yu-Hong Chen Hai‐Liang Zhang Xiao‐Feng Zhu Rong Deng

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Key Points

Enhanced antitumor immunity was observed in NRAS-mutant tumors when cGAS-STING signaling was activated.
In Kaplan-Meier analyses, patients with high interferon alpha response showed a better overall survival (OS) and progression-free survival (PFS).
This study utilizes data from the Cancer Genome Atlas (TCGA) for assessing the significance of the interferon response in melanoma patients.
Findings suggest that targeting cGAS-STING pathways could be crucial for treatment strategies in melanoma.

Implication

Kaplan-Meier analyses reveal improved survival outcomes in NRAS wild-type melanoma, indicating cGAS-STING may enhance antitumor immunity.

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Cite This Study

Shan et al. (2025) studied this question.

synapsesocial.com/papers/68af509bad7bf08b1ead8821 https://doi.org/10.1158/0008-5472.29918753

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Data from Reactivating cGAS–STING Signaling by Targeting SOS1 Enhances Antitumor Immunity in <i>NRAS</i>-Mutant Tumors2025 · 1 citations
2Supplementary Source Data from Reactivating cGAS–STING Signaling by Targeting SOS1 Enhances Antitumor Immunity in <i>NRAS</i>-Mutant Tumors2025
3Figure S3 from Reactivating cGAS–STING Signaling by Targeting SOS1 Enhances Antitumor Immunity in <i>NRAS</i>-Mutant Tumors2025
4Figure S2 from Reactivating cGAS–STING Signaling by Targeting SOS1 Enhances Antitumor Immunity in <i>NRAS</i>-Mutant Tumors2025
5Figure 6 from Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity2024

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