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August 13, 2025Open Access

Advancements in antivenom therapy: Historical perspectives, current challenges, and ongoing clinical trials

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Authors

LRLuís Roque

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Overview

Review highlights clinical trials and biotechnological innovations to improve antivenom for snakebite envenomation.

Key Points

  • Antivenom therapy struggles to meet the needs of global healthcare, particularly in rural, tropical areas, suggesting a need for innovative solutions.
  • Despite more than 125 years of advancements, challenges like species specificity and immunologic reactions continue to hinder antivenom efficacy.
  • This review analyzes historical developments and current limitations in antivenom therapy while focusing on promising clinical trials aiming to enhance treatment.
  • The findings underscore the critical importance of translational research to address therapeutic gaps and improve outcomes for snakebite victims.

Cite This Study

Luís Roque (2025) studied this question.

synapsesocial.com/papers/68af50a1ad7bf08b1ead8a3ehttps://doi.org/10.36922/imo025240026
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  1. 1Advancements in Antivenom Therapy: Historical Perspectives, Current Challenges, and Ongoing Clinical Trials2025 · 1 citations
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  5. 5A Paradigm Shift in Snakebite Envenoming Therapy: From Conventional Antivenoms to Rationally Designed, Broadly Neutralizing Combination Therapies2026